Total Synthesis of Nannocystin A.
نویسندگان
چکیده
Nannocystin A is a 21-membered cyclodepsipeptide showing remarkable anticancer properties. Described is the total synthesis of nannocystin A, which features an asymmetric vinylogous Mukaiyama aldol reaction for efficient assembly of the penultimate open-chain precursor and a pivotal intramolecular Heck cross-coupling for the final macrocyclization.
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ورودعنوان ژورنال:
- Organic letters
دوره 18 21 شماره
صفحات -
تاریخ انتشار 2016